Figure 2.
Comparison of on- and off-rifampin (RIF) efavirenz (EFV) trough concentrations (Cmin) by race/ethnicity and by weight. On-RIF (closed triangle, solid line) and off-RIF (closed circle, dashed line) participant-specific mean EFV Cmin are presented as medians and 95% confidence intervals (CIs) around the medians. Data from 324 participants with both on- and off-RIF EFV Cmin values are plotted. The median within-participant on-RIF versus off-RIF EFV Cmin difference, number of participants contributing to each CI and a Wilcoxon signed-rank P value is shown. *Statistically significant difference (P ≤ 0.05). Two Asian male participants were omitted from the by-race/ethnicity comparison. Horizontal dashed lines at 1 and 4 µg/mL mark the commonly cited thresholds for sub- and supraoptimal EFV Cmin. Abbreviation: RIF, rifampin.