Table 2.
Associations Between Quantitative Plasma Marker Levels and Liver Disease Progression
|
Pa |
|||||
|---|---|---|---|---|---|
| Variable, by Time Point(s) | Overall | Progressors | Nonprogressors | Unadjusted | Adjustedb |
| T1 | n = 44 | n = 21 | n = 23 | ||
| LPS level, EU/mL (n = 43)c | 0.38 ± 0.33 | 0.35 ± 0.27 | 0.41 ± 0.38 | .53 | .59 |
| EndoCAb level, MMU/mL | 110.8 ± 82.5 | 99.5 ± 72.3 | 121.2 ± 91.3 | .39 | .42 |
| sCD14 level, pg/mL | 2359.9 ± 447.6 | 2510.7 ± 453.9 | 2222.2 ± 403.4 | .03 | .02 |
| IL-6 level, pg/mL | 3.1 ± 2.5 | 3.4 ± 2.0 | 2.9 ± 2.9 | .56 | .57 |
| IL-10 level, pg/mL | 10.6 ± 9.5 | 12.7 ± 12.5 | 8.8 ± 5.1 | .20 | .11 |
| TNF-α level, pg/mL | 2.2 ± 6.8 | 3.8 ± 8.8 | 0.6 ± 3.7 | .13 | .11 |
| I-FABP level, pg/mL | 476.1 ± 378.5 | 475.8 ± 356.6 | 476.4 ± 405.4 | .99 | .87 |
| T3 | n = 44 | n = 21 | n = 23 | ||
| LPS level, EU/mL | 0.32 ± 0.24 | 0.33 ± 0.18 | 0.32 ± 0.28 | .90 | .31 |
| EndoCAb level, MMU/mL | 87.7 ± 82.4 | 68.7 ± 63.6 | 105.0 ± 94.6 | .15 | .10 |
| sCD14 level, pg/mL | 2473.0 ± 607.6 | 2615.4 ± 603.7 | 2342.9 ± 594.3 | .14 | .33 |
| IL-6 level, pg/mL | 4.9 ± 3.8 | 5.5 ± 3.7 | 4.4 ± 3.9 | .33 | .69 |
| IL-10 level, pg/mL | 9.6 ± 4.7 | 9.9 ± 5.6 | 9.2 ± 3.7 | .63 | .74 |
| TNF-α level, pg/mL | 3.08 ± 8.1 | 3.2 ± 6.9 | 3.0 ± 9.2 | .94 | .97 |
| I-FABP level, pg/mL | 926.9 ± 799.3 | 1252.0 ± 1001.2 | 630.2 ± 380.2 | .01 | .001 |
| T1–3 | n = 132 | n = 63 | n = 69 | ||
| LPS level, EU/mL (n = 131)c | 0.37 ± 0.28 | 0.36 ± 0.25 | 0.37 ± 0.30 | .69 | .60 |
| EndoCAb level, MMU/mL | 97.9 ± 78.8 | 85.2 ± 66.7 | 109.4 ± 87.3 | .07 | .07 |
| sCD14 level, pg/mL | 2416.3 ± 531.0 | 2571.6 ± 483.6 | 2274.6 ± 536.0 | .001 | .003 |
| IL-6 level, pg/mL | 3.9 ± 3.3 | 4.6 ± 3.3 | 3.2 ± 3.2 | .02 | .04 |
| IL-10 level, pg/mL | 9.8 ± 6.9 | 11.0 ± 8.7 | 8.6 ± 4.6 | .05 | .04 |
| TNF-α level, pg/mL | 2.8 ± 7.7 | 3.8 ± 8.5 | 1.8 ± 6.9 | .13 | .14 |
| I-FABP level, pg/mL (n = 131)c | 673.2 ± 597.9 | 796.1 ± 734.5 | 559.4 ± 408.6 | .03 | .005 |
Data are mean ± SD. See Methods for definitions of T1–3.
Abbreviations: EndoCAb, antibody to endotoxin; EU, endotoxin units; I-FABP, intestinal fatty acid binding protein; IL-6, interleukin 6; IL-10, interleukin 10; LPS, lipopolysaccharide; MMU, immunoglobulin M median units; sCD14, soluble CD14; TNF-α, tumor necrosis factor α.
a By the t test.
b Adjusted for log human immunodeficiency virus RNA load.
c One subject did not have data for 1 visit.