Figure 7.

Binding of serum immunoglobulin G (IgG) anti–factor H binding protein (fHbp) antibodies from mice immunized with the recombinant fHbp ID 9 vaccine and complement deposition on strains with fHbp ID 1 (solid black line) or ID 55 (dashed black line). A, Binding of IgG anti-fHbp ID 9 antibodies (1:50 serum dilution) or negative control antiserum (1:50) from mice immunized with aluminum hydroxide alone (dotted grey line). B, C4b deposition by anti-fHbp ID 9 antiserum (1:50). C, C3b deposition by the anti-ID 9 antiserum (1:200). Experiments shown in B and C used 5% IgG-depleted human serum as the source of complement.