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. 2013 Mar 11;172(1):23–36. doi: 10.1111/cei.12029

Figure 6.

Figure 6

Characterization of T helper type 1 (Th1)-like cytokine secretion phenotypes. Lymphocytes were isolated from the spleens of immunized mice that were treated with either Ac-PLP-cIBR-NH2-1 or phosphate-buffered saline (PBS) on days 4 and 7. The pooled lymphocytes in triplicate were stimulated with mitomycin-treated syngeneic splenocytes (1:10) and proteolipid protein (PLP)139–151 for 48 h. Following activation and cytokine production, the supernatants were analysed for various cytokines. Statistical significance values compared to those for PBS are as follows: (a) Ac-PLP-cIBR-NH2-1 (P < 0·001, day 13; P > 0·05, day 35), lovastatin (P < 0·01, day 13; P < 0·05, day 35), (b) Ac-PLP-cIBR-NH2-1 (P < 0·05, day 13; P < 0·05, day 35), lovastatin (P > 0·05, day 13; P > 0·05, day 35), (c) Ac-PLP-cIBR-NH2-1 (P < 0·0001, day 13; P < 0·05, day 35), lovastatin (P < 0·0001, day 13; P < 0·001, day 35) and (d) Ac-PLP-cIBR-NH2-1 (P < 0·0001, day 13; P < 0·05, day 35) and lovastatin (P < 0·0001, day 13; P > 0·05, day 35).