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. 2013 Mar 11;172(1):44–53. doi: 10.1111/cei.12033

Figure 3.

Figure 3

(a) Association between the HLA-DRB1 shared epitope (SE) allele and anti-citrullinated glucose-6-phosphate isomerase peptide-1–9 (CCG-1–9), anti-citrullinated α-enolase peptide (CEP)-1 and anti-cyclic citrullinated peptides (CCP) antibodies. Patients with rheumatoid arthritis (RA) were divided according to the HLA-DRB1 SE genotype into two groups and positivity for anti-CCG-1–9, anti-CEP-1 and anti-CCP antibodies was evaluated for each antibody. Anti-CCG-2, -4 and -7, anti-CEP-1 and anti-CCP antibodies were associated with the presence of HLA-DRB1 SE alleles. SE 0: patients with null SE alleles (n = 41); SE 1: patients with 1 SE alleles (n = 75); SE 2: patients with 2 SE alleles (n = 31); *P < 0·05; **P < 0·01; ***P < 0·001. (b) Percentage of the population of SE in RA patients with anti-CCG-2, -4 and -7, anti-CEP-1 and anti-CCP antibodies. A high proportion of anti-CCG-2, -7 and anti-CEP-1 antibody-positive patients carried one or two HLA-DRB1 SE alleles.