Table 1.
Antibody response to citrullinated peptides in patients with rheumatoid arthritis (RA) and in controls*
| Antigen | Sequence | RA (n = 208) | SLE (n = 101) | SS (n = 101) | HS (n = 174) | RA versus controls (SLE, SS, HS) |
|---|---|---|---|---|---|---|
| CCG-1 | CKLQQWYXEHXSELNLXXLFC | 8·7 | 0 | 0 | 0 | 100 |
| CCG-2 | CDLAKSXGVEAAXEXMFNGEC | 25·5 | 0 | 0 | 0·6 | 99·7 |
| CCG-3 | CNYTEGXAVLHVALXNXSNTC | 14·4 | 6·0 | 15·8 | 1·7 | 93·4 |
| CCG-4 | CSFCQXVXSGDWKGYTGKTIC | 33·2 | 2·0 | 4·0 | 0·6 | 98·1 |
| CCG-5 | CFEFWDWVGGXYSLWSAIGLC | 3·4 | 2·0 | 0 | 1·7 | 98·7 |
| CCG-6 | CAMLPYDQYLHXFAAYFQQGC | 0·5 | 0 | 1·0 | 0·6 | 99·5 |
| CCG-7 | CALMXGKSTEEAXKELQAAGC | 37·0 | 2·0 | 0 | 1·2 | 98·9 |
| CCG-8 | CEDLEXLLPHKVFEGNXPTNC | 25·0 | 8·9 | 2·0 | 1·7 | 96·3 |
| CCG-9 | CASTNGLINFIKQQXEAXVQC | 5·8 | 5·0 | 0 | 1·7 | 97·9 |
| CEP-1 | CKIHAXEIFDSXGNPTVEC | 44·2 | 2·0 | 0 | 1·2 | 98·9 |
| CCP | 86·1 | 6·9 | 3·4 | 1·2 | 97·3 |
*
Values represent the percentages of positivity (RA, systemic lupus erythematosus (SLE), Sjögren's syndrome (SS) and healthy control subjects (HS)] or specificity (RA versus controls). RA versus controls: specificity of the negative reaction rate compared with those of the HS and disease controls. X = citrulline.