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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Drug Deliv Transl Res. 2013 Feb 16;3(4):336–351. doi: 10.1007/s13346-013-0133-3

Table 3.

Intranasal delivery of other macromolecules

Molecules Class Function/Use Reference
ADRSVBgal adenoviral vectors Detected by histochemical, Intracellular axonal Pathway β-galactosidase activity was detected in the olfactory bulb, locus ceruleus, area postrema, brainstem, and hippocampus 12 days following IN delivery [106]
Semliki Forest Virus-EGFP IL-10 vector IL-10 expression seen in nasal passage and olfactory bulb in the infected mice [107]
Plasmid DNA Gene vector DNA plasmid expression confirmed in the brain tissues and the lymph nodes by qPCR [108]
Apha B-crytallin siRNA siRNA In 12 hours gene reduction was observed in amygdada,entorhinal cortex, and hypothalamus detected by immunohistochemistry [109]
FITC-siRNA siRNA siRNA detected along the olfactory nerve bundles and in the olfactory bulbs [110]
Mesenchymal stem cells Whole cells MSC in PD animal model and were detected in olfactory bulbs and other parts of brain and cells survived upto 4.5months. Showed improvement in forepaw motor function after in delivery [111]