TABLE 1.
Characteristics of patients admitted with bone and joint infections and antimicrobial therapy pre- and postpolymerase chain reaction result
| Patient | Age, years/sex | Admitting diagnosis | Pretest infectious disease opinion | Antibiotics pretest | 16S result | Antibiotics post-test | Antibiotic use consistent with 16S result? |
|---|---|---|---|---|---|---|---|
| 1 | 43/F | Osteomyelitis | Rule out | No | Negative | No antibiotic | Yes |
| 2 | 36/F | Osteomyelitis | Rule in | Yes | Negative | Doxycycline, linezolid | No |
| 3 | 70/F | Osteomyelitis | Rule out | Yes | Negative | Metronidazole | Yes* |
| 4 | 55/M | Other noninfectious joint inflammation† | Rule in | No | Negative | No antibiotic | Yes |
| 5 | 65/M | Other noninfectious joint inflammation† | Rule out | Yes | Negative | No antibiotic | Yes |
| 6 | 48/F | Other noninfectious joint inflammation† | Rule out | Yes | Negative | No antibiotic | Yes |
| 7 | 67/F | Prosthetic joint infection | Rule in | Yes | Streptococcus species | Vancomycin | Yes |
| 8 | 74/M | Prosthetic joint infection | Rule out | Yes | Negative | 1st-generation cephalosporin | No |
| 9 | 68/F | Prosthetic joint infection | Rule out | Yes | Negative | No antibiotic | Yes |
| 10 | 83/M | Prosthetic joint infection | Rule out | Yes | Negative | Metronidazole | Yes |
| 11 | 59/M | Prosthetic joint infection | Rule in | No | Negative | No antibiotic | Yes |
| 12 | 81/F | Prosthetic joint infection | Rule in | Yes | Negative | 1st-generation cephalosporin | No |
| 13 | 83/F | Prosthetic joint infection | Rule in | Yes | Bacteroides species | Metronidazole | Yes |
| 14 | 83/M | Prosthetic joint infection | Rule out | Yes | Staphylococcus species | 1st-generation cephalosporin | Yes |
| 15 | 56/M | Prosthetic joint infection | Rule in | Yes | Negative | Vancomycin and rifampin | No |
| 16 | 75/F | Prosthetic joint infection | Rule out | Yes | Negative | No antibiotic | Yes |
| 17 | 63/M | Prosthetic joint infection | NA | No | Negative | No antibiotic | Yes |
| 18 | 67/F | Prosthetic Joint Infection | Rule in | Yes | Klebsiella oxytoca | 3rd-generation cephalosporin, penicillin | Yes |
| 19 | 75/M | Prosthetic joint infection | Rule in | Yes | Streptococcus pneumoniae | Penicillin | Yes |
| 20 | 56/F | Prosthetic joint infection | Rule out | Yes | Negative | 1st-generation cephalosporin | No |
| 21 | 51/F | Prosthetic joint infection | Rule out | No | Negative | No antibiotic | Yes |
| 22 | 70/M | Prosthetic joint infection | NA | Yes | Negative | No antibiotic | Yes |
| 23 | 67/M | Prosthetic joint infection | Rule in | Yes | Negative | 1st-generation cephalosporin | No |
| 24 | 17/M | Septic arthritis | Rule in | Yes | Negative | No antibiotic | Yes |
| 25 | 57/F | Septic arthritis | Rule in | Yes | Negative | 3rd-generation cephalosporin | No‡ |
| 26 | 42/M | Septic arthritis | Rule out | Yes | Streptococcus pyogenes | 3rd-generation cephalosporin, penicillin | Yes |
| 27 | 90/M | Septic arthritis | Rule out | Yes | Negative | No antibiotic | Yes |
| 28 | 63/M | Septic arthritis | Rule in | Yes | Negative | No antibiotic | Yes |
| 29 | 74/M | Septic arthritis | Rule in | Yes | Negative | FQ and rifampin | No |
| 30 | 58/M | Septic arthritis | Rule in | Yes | Negative | No antibiotic | Yes |
| 31 | 51/F | Septic arthritis | Rule in | Yes | Negative | No antibiotic | Yes |
| 32 | 69/F | Septic arthritis | Rule in | No | Negative | Vancomycin, FQ and rifampin | No |
| 33 | 18/M | Septic arthritis | Rule in | Yes | Negative | Vancomycin, FQ and rifampin | No |
| 34 | 60/F | Septic arthritis | NA | No | Negative | No antibiotic | Yes |
| 35 | 74/M | Septic arthritis | Rule in | Yes | Negative | No antibiotic | Yes |
| 36 | 80/F | Septic arthritis | Rule in | Yes | Staphylococcus lugdunensis | 1st-generation cephalosporin | Yes |
*
Patient had Clostridium clostridioforme superficial culture;
†
Gout, osteoarthritis, loose prosthesis;
‡
Patient had Streptococcus bovis isolated from a blood culture. F Female; FQ Fluoroquinolone; M Male; NA Not seen by an infectious disease consultant