Table 2. Genotype and allele frequencies of the HIF1A polymorphisms among the PCa cases and controls.
| Polymorphisms | Cases (n=662) | Controls (n=716) | Pa | Adjusted OR (95%CI)b | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| HIF1A rs11549465 | ||||||
| CC | 612 | 92.5 | 659 | 92.0 | 0.302 | 1.00 (reference) |
| CT | 48 | 7.2 | 57 | 8.0 | 0.91 (0.61–1.37) | |
| TT | 2 | 0.3 | 0 | 0.0 | — | |
| CT+TT | 50 | 7.5 | 57 | 8.0 | 0.708 | 0.95 (0.64–1.42) |
| C | 1272 | 96.1 | 1375 | 96.0 | 0.943 | |
| T | 52 | 3.9 | 57 | 4.0 | ||
| Ptrend | 0.943 | |||||
| HIF1A rs11549467 | ||||||
| GG | 614 | 92.8 | 685 | 95.7 | 0.048 | 1.00 (reference) |
| GA | 47 | 7.0 | 31 | 4.3 | 1.66 (1.04–2.67) | |
| AA | 1 | 0.2 | 0 | 0 | — | |
| GA+AA | 48 | 7.2 | 31 | 4.3 | 0.020 | 1.70 (1.06–2.72) |
| G | 1275 | 96.3 | 1401 | 97.8 | 0.281 | |
| A | 49 | 3.7 | 31 | 2.2 | ||
| Ptrend | 0.016 | |||||
| HIF1A rs2057482 | ||||||
| CC | 418 | 63.1 | 428 | 59.8 | 0.258 | 1.00 (reference) |
| CT | 212 | 32.0 | 241 | 33.7 | 1.31 (0.80–2.15) | |
| TT | 32 | 4.8 | 47 | 6.6 | 1.44 (0.90–2.32) | |
| CT+TT | 244 | 36.9 | 288 | 40.2 | 0.200 | 1.40 (0.87–2.31) |
| C | 1048 | 79.2 | 1097 | 76.6 | 0.108 | |
| T | 276 | 20.8 | 335 | 23.4 | ||
| Ptrend | 0.116 | |||||
Abbreviations: CI, confidence interval; OR, odds ratio; PCa, prostate cancer.
a
Two-sided χ2 test for either genotype distributions or allele frequencies between the cases and controls.
b
Adjusted for age, smoking, drinking status and family history of cancer in logistic regression model.