Table 3. Stratification analyses between HIF1A rs11549467 polymorphisms and risk of PCa.

Variables	Cases/controls	Genotypes (cases/controls)				Pa	Adjusted OR (95%CI)b GA+AA vs. GG
		GG		GA+AA
		n	%	n	%
Total	662/716	614/685	92.8/95.7	48/31	7.2/4.3	0.020	1.70 (1.06–2.72)
Age (year)
≤71	308/360	288/344	93.5/95.6	20/16	6.5/4.4	0.242	1.41 (0.71–2.81)
>71	354/356	328/341	92.1/95.8	28/15	7.9/4.2	0.039	2.01 (1.05–3.86)
Smoking status
Never	277/350	258/333	93.1/95.1	19/17	6.9/4.9	0.285	1.37 (0.69–2.71)
Ever	385/366	356/352	92.5/96.2	29/14	7.5/3.8	0.029	2.06 (1.07–3.99)
Drinking status
Never	468/541	434/522	92.7/96.5	34/17	7.3/3.5	0.008	2.16 (1.20–3.86)
Ever	194/175	180/163	92.8/93.1	14/12	7.2/6.9	0.893	1.07 (0.48–2.40)
Family history of cancer
No	493/607	457/581	92.7/95.7	36/26	7.3/4.3	0.031	1.71 (1.02–2.89)
Yes	169/109	157/104	92.9/95.4	12/5	7.1/4.6	0.393	1.58 (0.54–4.63)

Abbreviations: CI, confidence interval; OR, odds ratio; PCa, prostate cancer.

^aTwo-sided χ² test for the distributions between the cases and controls.

^bAdjusted for age, smoking, drinking status and family history of cancer in logistic regression model.