Table 4. Frequency distributions of the combined genotypes of rs11549467 G>A and rs2057482 C>T polymorphisms among the cases and controls, and their correlation to risk of PCa.
| Cases (n=662) | Controls (n=716) | Pb | Adjusted OR (95%CI)c | |||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| Number of risk allelesa | ||||||
| 0 | 32 | 4.8 | 46 | 6.4 | 0.037 | 1.00 (reference) |
| 1 | 206 | 31.1 | 234 | 32.7 | 1.28 (0.78–2.11) | |
| 2 | 382 | 57.7 | 414 | 57.8 | 1.34 (0.83–2.16) | |
| 3 | 41 | 6.2 | 22 | 3.1 | 2.65 (1.32–5.31) | |
| 4 | 1 | 0.2 | 0 | 0.0 | — | |
| Ptrend | 0.023 | |||||
| Recombined groupsa | ||||||
| 0–2 | 620 | 93.7 | 694 | 97.0 | 0.004 | 1.00 (reference) |
| 3–4 | 42 | 6.3 | 22 | 3.1 | 2.10 (1.23–3.57) | |
Abbreviations: CI, confidence interval; OR, odds ratio; PCa, prostate cancer.
a
The 0–4 represents the numbers of risk alleles within the combined genotypes; the risk alleles used for the calculation were the rs11549467 A and rs2057482 C alleles.
b
Two-sided χ2 test for the distributions between the cases and controls.
c
Adjusted for age, smoking, drinking status and family history of cancer in logistic regression model.