Fig. 6.
Responses of field-stimulated Ca2+ transient measures to SNX-111 (200 nm) in small (A) and large (B) sensory neurons, to SNX-482 (100 nm) in small neurons (C), to nitrendipine (10 μm) or nisoldipine (200 nm) in small neurons (D; results did not differ and were combined), and to ω-agatoxin-IVA (200 nm) in large neurons (E). Agents were applied to control neurons and neurons dissociated from the fourth lumbar (L4) and L5 ganglion of rats after spinal nerve ligation (SNL). Each neuron was exposed to only a single agent. Results for neuronal groups without significant changes are not shown. An asterisk within the bar indicates a significant effect on the transient after application compared with baseline. Numbers in parentheses are main effect of injury using one-way analysis of variance or t test. Brackets indicate significant differences by post hoc paired comparisons. C = control; RΔmax = transient amplitude. Numbers at the base of the bars are number of neurons per group.