Table 2. Molecular markers of normal adult stem cells in various organs, and their expression in the epididymis without evidence that they are stem cell markers.
Braina | Liver | Intestine | Kidney | Prostate | Epididymal transcriptb | Epididymal proteinc | |
---|---|---|---|---|---|---|---|
Mouse/human | Human | Mouse/human | Human | Mouse/human | Human | Mouse/bull/human | |
Abcg2 | + | + (Ref. 20) | Mouse caput epithelial microvilli, caput and corpus interstitial endothelial cells165 | ||||
Ascl 2 | + | + (Ref. 20) | |||||
Bmi-1 | + | + | |||||
CD9 | + | + (Ref. 20) | Bull corpus and cauda epithelium166 | ||||
CD24 | + | + (Refs. 20 and 38) | |||||
CD29 | + | Human cultured cells8 | |||||
CD44 | + | + (Refs. 20 and 38) | Human cultured cells; mouse basal cells8 | ||||
CD49b | + | ||||||
CD49f | + | ||||||
CD73 | + | ||||||
CD81 | + | + (Refs. 20 and 38) | |||||
CD90 | + | ||||||
CD95 | + | ||||||
CD117 | + | ||||||
CD133 | + | + | + | + | Human cultured cells (j); mouse principal cells microvilli except initial segment167 | ||
CD144 | + | ||||||
CD146 | + | + | |||||
CD184 | + | ||||||
CK6a | + | ||||||
DCAMKL-1 | + | + (Ref. 20) | |||||
EpCAM | + | ||||||
Lgr5 | + | + (Ref.20) | |||||
Musashi-1 | + | ||||||
mTERT | + | ||||||
Nestin | + | + (Ref. 38) | |||||
OLFM4 | + | + (Ref. 20) | |||||
PTEN | + | + (Ref. 20) | Mouse caput epithelium apical surface, especially initial segment stereocilia21 | ||||
Sca-1 | + | ||||||
sFRP5 | + | + (Ref. 20) | |||||
SOX4 | + | + (Ref. 20) | |||||
SOX9 | + | + (Ref. 20) | |||||
WIP1 | + | ||||||
Reference | 6 | 161 | 162 | 12 | Murine,163, 164 | 20, 38 | 8, 21, 165–167 |
human13 |