Table 1. Significant transcriptome modifications in WPMY myofibroblasts were induced by exposure to human serum collected after oral intake of Pygeum africanum (HS2) relative to the transcriptome of cells exposed to human serum collected before oral intake of Pygeum africanum (HS1).
| Gene symbol | Gene name | Gene ID | Ratio HS2/HS1 | Activity | Significant biological process and/or role |
|---|---|---|---|---|---|
| ELK4 | ETS-domain protein (SRF accessory protein 1) | 2005 | 3.26 | Upregulated | Regulation of transcription, MAPK signalling pathway |
| ZXDB | Zinc-finger, X-linked, duplicated B | 158586 | 2.39 | Regulation of transcription | |
| FGFR1 | Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 2260 | 2.38 | Cell growth, MAPK signalling pathway, regulation of actin skeleton | |
| ANKRD12 | Ankyrin repeat domain 12 | 23253 | 2.27 | Attachment of membrane proteins to the cytoskeleton | |
| GIGYF2 | GRB10 interacting GYF protein 2 | 26058 | 2.26 | Tyrosine kinase receptor activation | |
| AP1S2/LOC653653 | Adaptor-related protein complex 1, sigma 2 subunit/similar to adaptor-related protein complex 1 sigma 2 subunit | 653653/8905 | 2.20 | Intracellular protein vesicle-mediated transport | |
| ASNS | Asparagine synthetase | 440 | 2.18 | Amino-acid biosynthetic process, nitrogen metabolism | |
| SMG1 | PI-3 kinase-related kinase SMG-1 | 23049 | 2.17 | mRNA catabolic process, nonsense-mediated decay, DNA repair, response to stress, phosphorylation of p53 | |
| ZEB2 | Zinc-finger E-box binding homeobox 2 | 9839 | 2.11 | Negative regulation of transcription, TGF-beta signalling pathway | |
| IDS | Iduronate 2-sulfatase (Hunter syndrome) | 3423 | 2.10 | Metabolic process, glycosaminoglycan degradation | |
| KRIT1 | Ankyrin repeat containing | 889 | 2.07 | Signal transduction, potential tumour suppressor gene | |
| ZNF354A | Zinc-finger protein 354A | 6940 | 2.02 | Regulation of transcription | |
| LOC728411 | Similar to beta-glucuronidase precursor | 728411 | 0.49 | Downregulated | Unknown |
| TMEFF2 | Transmembrane protein with EGF-like and two follistatin-like domains 2 | 23671 | 0.49 | Cell growth | |
| OPHN1 | Oligophrenin 1 | 4983 | 0.47 | Signal transduction, actin cytoskeleton organisation and biogenesis | |
| ATF6 | Activating transcription factor 6 | 22926 | 0.46 | Response to stress, positive regulation of unfolded protein response gene transcription | |
| MPV17L | MPV17 mitochondrial membrane protein-like | 255027 | 0.46 | Downregulates reactive oxygen species | |
| TPST1 | Tyrosylprotein sulfotransferase 1 | 8460 | 0.46 | Inflammatory response | |
| C1orf181 | Chromosome 1 open reading frame 181 | 54680 | 0.46 | Metal and zinc ion binding | |
| SLC25A16 | Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 | 8034 | 0.44 | Transport | |
| MALAT1 | Metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | 378938 | 0.43 | Unknown | |
| KLC1 | Kinesin light chain 1 | 3831 | 0.40 | Microtubule motor activity | |
| MRP63 | Mitochondrial ribosomal protein 63 | 78988 | 0.37 | Translation | |
| SCD5 | Stearoyl-CoA desaturase 5 | 79966 | 0.28 | Fatty-acid biosynthetic process | |
| RASEF | RAS and EF-hand domain containing | 158158 | 0.21 | Signal transduction, potential oncogene |
Abbreviations: EGF, epidermal growth factor; MAPK, mitogen-activated protein kinase; PI, phosphatidylinositol; TGF, transforming growth factor.