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. 2013 Jul 4;13:157. doi: 10.1186/1472-6882-13-157

Figure 5.

Figure 5

Hypothetic mechanisms of NGF and mushroom aqueous extracts in promoting neuritogenesis in PC-12 cells. Both nerve growth factor and aqueous extracts bind to tyrosine receptor, TrkA and initiate two major signaling pathways, the MEK/ERK1/2 and PI3K/Akt pathways. Activation of MEK/ERK1/2 and PI3K/Akt cascade promotes neuritogenesis of PC-12 cells. In the present study, the MEK/ERK1/2 inhibitors (U0126, PD98059) and PI3K/Akt inhibitor (LY294002) blocked the neuritogenic activity of NGF and aqueous extracts. Therefore, based on the present findings, the activation of MEK/ERK1/2 and PI3K/Akt signaling pathways are needed for the NGF and aqueous extracts in promoting neuritogenesis.