Fig. 4.
Growth and pathogenicity of SeV Cm* in wild-type and STAT1−/− mice. Five-week-old wild-type STAT1+/+ 129S6 and STAT1 deficient (STAT1−/−) 129S6 mice were infected intranasally with 107 CIU of SeV Wt or SeV Cm*. Two or three mice from each group were sacrificed at the intervals indicated and examined for virus infectivity in the lung (top) and lung consolidation (bottom). The symbol “†” indicates a dead mouse. Actual macroscopic views of the lung corresponding to the consolidation scores of 0 (no lesion) through 4 (maximum) are presented as references (right). When a mouse died, one point was added to the consolidation score (score 5) (Modified from Ref. 26).