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. 2008 Dec;84(10):439–451. doi: 10.2183/pjab/84.439

Fig. 5.

Fig. 5

Replication and pathogenicity of SeV V(-) and SeV VΔC in IRF3−/− mice. (A) Five-week-old IRF3+/+ C57BL/6J and IRF3 deficient (IRF3−/−) C57BL/6J mice were infected intranasally with 107 CIU of SeV Wt, SeV V(-) or SeV VΔC. Two or three mice from each group were sacrificed at the indicated intervals and examined for virus infectivity in the lung and lung consolidation. The symbol “†” indicates a dead mouse. (B) Six- to seven-week-old IFN-α/β R+/+ A129/Sv and IFN-α/β receptor deficient (IFN-α/β R−/−) A129/Sv mice were infected intranasally with 107 CIU of SeV Wt or SeV V(-) (left). Five-week-old STAT1+/+ 129S6 and STAT1 deficient (STAT1−/−) 129S6 mice were infected intranasally with 107 CIU of SeV Wt or SeV V(-) (right). Viral infectivity in the lung was measured at the indicated time intervals after infection (Modified from Ref. 30).