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. 2013 Jul 23;8(7):e69246. doi: 10.1371/journal.pone.0069246

Figure 3. Blockade of HIF-1α activity in vivo reduces lung eosinophilia induced by HDM exposure.

Figure 3

Mice were treated with PBS or HDM intranasally for 5 weeks, and chetomin was administrated intraperitoneally 20 minutes prior to each challenge. IL-13 levels were measured by ELISA in lung tissue (panel A). Mean ± SEM number of eosinophils in the lung (panel B). IL-5 (panel C), eotaxin 2 (panel D) and eotaxin 2 (panel E) were measured in the lung tissue homogenates by ELISA. *represents p<0.05. n = 4–8 mice per experimental group.