Table 1. Summary of CUSP9, listing the drugs with a short unreferenced description of the rationale or expected advantage accruing from its use.

References are given in the text.

DRUG	EXPECTED BENEFIT
aprepitant	Nausea reduction, inhibit growth by blocking NK-1R
artesunate	Increase ROS, empirical anti-glioma effects, survivin inhibition
sertraline	Empirical longer OS, improved mood, documented anti-proliferation effect in glioma cells
captopril	Empirical longer OS, MMP-2 & MMP-9 inhibition, prevents AT-2 stimulation, lowers IL-18 stimulated VEGF, TNF, & IL-8
auranofin	Thioredoxin reductase inhibition, cathepsin B inhibition, increased i.c. ROS, empirical [& potentially dangerous] synergy with artesunate,
nelfinavir	HSP90 inhibition, MMP-2 & MMP-9 inhibition, decreased signaling at multiple receptors, i.a. TGF-beta, increased i.c. ROS, decreased AKT activation, lower VEGF, IL-8, ICE inhibition
temozolomide	A common & accepted treatment for recurrent glioblastoma
disulfiram	ALDH inhibition, glutathione inhibition, increase ROS, lowers IL-18 stimulated VEGF, TNF, & IL-8, MMP-2 & MMP-9 inhibition, proteosome inhibition, SOD inhibition, P-glycoprotein inactivation, MGMT inhibition.
Cu gluconate	Adequate Cu may be a requirement for disulfiram activity
ketoconazole	Drug efflux inhibitor at BBB, permits higher brain ritonavir (or nelfinavir) concentrations, 5-lipoxygenase inhibitor, thromboxane synthase inhibitor, empirical anti-glioma effect