Figure 3. Depletion of GAGE and XAGE1 in the melanoma cell line SK-MEL-37 results in reduced migration and invasion.

Transwell migration and invasion assays with SK-MEL-37 cells treated with nontargeting siRNA, GAGE-specific or XAGE1-specific siRNAs. All experiments were repeated at least three times and representative data are presented. The knock down levels of GAGE and XAGE1 in these experiments were confirmed by real-time PCR. Bars, SD. *, P < 0.05 relative to non-targeting siRNA.