Skip to main content
. 2013 Jul 23;8(7):e69477. doi: 10.1371/journal.pone.0069477

Figure 4. SiRNA in-vivo knockdown of UNC5B attenuates myocardial IR injury in WT mice.

Figure 4

A) Infarct size of mice with UNC5B specific siRNA treatment compared to mice received non-targeting siRNA after 60 minutes of myocardial ischemia followed by 2 hours reperfusion. Calculated is the percentage of necrotic tissue to AAR. B) and C) Correlating serum Troponin I and IL-6 levels of these mice (n = 6 per group; *P<0.05; ***P<0.001 as indicated). D) Representative TTC stained heart slices of myocardial infarcts (blue/dark = retrograde Evans blue staining; red and white = AAR; white = infracted tissue) of the siRNA treated mice.