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Schematic diagram depicting RET fusions identified in non-small cell lung cancer. The RET tyrosine kinase domain (blue) is preserved in all fusions. Four different RET fusion partners are depicted: KIF5B, CCDC6, TRIM33, and NCOA4. KIF5B is the most common fusion partner, with seven different KIF5B-RET fusion variants described to date.
Abbreviation: TM, transmembrane.
