Table 1.

Prevalence of ROS1 rearrangements in non-small cell lung cancer screening studies

^aScreened specimens consisted entirely of resected adenocarcinomas from never-smokers who were negative for alterations in EGFR, KRAS, HER2, ALK, and BRAF.

^bIdentified in cell line.

^cScreened specimens consisted of “pan-negative” adenocarcinomas (negative for alterations in EGFR, KRAS, BRAF, MEK1, HER2, and ALK).

Abbreviations: FISH, fluorescence in situ hybridization; IHC, immunohistochemistry; RT-PCR, reverse transcription polymerase chain reaction.