Figure 3. Proportions of dogs “sensitive” and “insensitive” to induction of chromosomal damage following bleomycin exposure.

Dogs were defined as “sensitive” if the number of gross chromatid breaks exceeded the 75^th percentile of the reference (normal mixed-breed dog) population. The proportion of dogs demonstrating sensitivity to induction of damage following bleomycin exposure was higher in golden retrievers with lymphoma (LSA) than in clinically normal golden retrievers (GR) or normal mixed-breed dogs (MBD), which even though it did not reach statistical significance (p = 0.10 and 0.11 for 4 and 24 hours respectively, LSA vs GR), does support DNA repair deficiency in the golden retrievers with lymphoma.