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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: DNA Repair (Amst). 2013 May 13;12(8):600–604. doi: 10.1016/j.dnarep.2013.04.012

Figure.

Figure

Hippocampal neurons of the CA1 field of the human hippocampus immunostained to detect HDAC4 location. In elderly individuals with no cognitive impairment (CDR 0), most neuronal HDAC4 is located in cytoplasm. In individuals with early (CDR 0.5) or late (CDR 3) stage Alzheimer’s disease, neurons with prominent nuclear HDAC4 (examples highlighted with pink arrows) become more frequent. The histogram represents the quantification of these results from 6 individuals with each condition. Different by Student’s t-test: * p ≤ 0.05; ** p ≤ 0.01.