. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Clin Pharmacokinet. 2013 Aug;52(8):615–626. doi: 10.1007/s40262-013-0071-8

Table I.

Physicochemical properties of Cholesterol Ester Transfer Protein (CETP) inhibitors

Drug	Pharmaceutical company	Molecular formula	XLogP	Topological Polar Surface Area (Angstrom squared)	CETP IC₅₀ (nM)^[67]
Torcetrapib	Pfizer	C₂₆H₂₅F₉N₂O₄	7.0	59.1	39
Dalcetrapib	Hoffmann La-Roche	C₂₃H₃₅NO₂S	7.1	71.5	NA
Anacetrapib	Merck & Co.	C₃₀H₂₅F₁₀NO₃	8.8	38.8	46
Evacetrapib	Eli Lilly & Company	C₃₁H₃₆F₆N₆O₂	7.7	87.4	26

NA: not available

IC₅₀ concentration of compound causing a 50% inhibition of CETP activity

Unless otherwise stated, all information were obtained from Pubchem compound (http://pubchem.ncbi.nlm.nih.gov/)