Table I.
Drug | Pharmaceutical company | Molecular formula | XLogP | Topological Polar Surface Area (Angstrom squared) | CETP IC50 (nM)[67] |
---|---|---|---|---|---|
Torcetrapib | Pfizer | C26H25F9N2O4 | 7.0 | 59.1 | 39 |
Dalcetrapib | Hoffmann La-Roche | C23H35NO2S | 7.1 | 71.5 | NA |
Anacetrapib | Merck & Co. | C30H25F10NO3 | 8.8 | 38.8 | 46 |
Evacetrapib | Eli Lilly & Company | C31H36F6N6O2 | 7.7 | 87.4 | 26 |
NA: not available
IC50 concentration of compound causing a 50% inhibition of CETP activity
Unless otherwise stated, all information were obtained from Pubchem compound (http://pubchem.ncbi.nlm.nih.gov/)