Figure 1. Cellular localization of the functions attributable to the genes up-regulated by GABAr blockage.

Gene functions, extracted from findings reported in the literature, are categorized in four main groups, indicated by the terms: Syn.Tra, regulation of synaptic transmission, growth, regulation of growth, neurogen., regulation of hippocampal neurogenesis, survival, regulation of survival. Each gene is counted as PRO when it positively regulates these processes, while it is counted as ANTI when it negatively affects these processes. The cellular compartment of action for each protein(gene) is chosen according to the indications reported in the literature. For example, it has been shown that the pentraxin Nptx2 (neuronal activity–regulated pentraxin) is localized in the excitatory synapses, where it exerts a homeostatic effect by recruiting AMPAr, AMPA receptors, at excitatory projections onto gabaergic interneurons [118]–[121].