Table 3. Detected complexes of mitoribosomal proteins together with previously identified interactors by hierarchical clustering.
39S mitoribosome | 28S mitoribosome | 300 kDa subcomplex | 200 kDa subcomplex |
MRPL1* | MRPL45* | MRPL18* | MRPL10* |
MRPL13* | MRPS10* | MRPS16* | MRPL12* |
MRPL15* | MRPS11* | MRPS17* | MRPL53* |
MRPL17* | MRPS14* | MRPS18B* | C14ORF156 (SLIRP) |
MRPL18* | MRPS15* | MRPS25* | LRPPRC |
MRPL2* | MRPS16* | MRPS26* | COX2 |
MRPL21* | MRPS17* | MRPS27* | COX4L1 |
MRPL22* | MRPS18B* | MRPS34* | |
MRPL23* | MRPS21* | ACAD9 | |
MRPL24* | MRPS22* | TMEM126A | |
MRPL37* | MRPS23* | NDUFA4 | |
MRPL38* | MRPS24* | PYCR1 | |
MRPL39* | MRPS25* | PYCR2 | |
MRPL4* | MRPS27* | VDAC1 | |
MRPL41* | DAP3 (MRPS29)* | VDAC3 | |
MRPL43* | MRPS31* | CCDC109A | |
MRPL44* | MRPS34* | HADHA | |
MRPL49* | MRPS35* | HADHB | |
MRPL9* | MRPS5* | HSPD1 | |
MRPS30* | MRPS7* | ||
AFG3L2 | MRPS9* | ||
DBT | PHB | ||
DLST | PHB2 | ||
ERLIN2 | PTCD3 | ||
FASTKD5 | |||
GADD45GIP1 | |||
ICT1 | |||
STOML2 |
Migration profiles from mitochondrial ribosomal proteins and previously identified interactors were subjected to hierarchical clustering analysis to examine possible co-migration. Proteins from the mitoribosome are marked with an asterisk and functionally validated interactors are bold and underlined. Co-purified proteins from selected AP-MS studies are italic.