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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Pharmacoepidemiol Drug Saf. 2013 May 2;22(8):842–849. doi: 10.1002/pds.3447

Table 1.

Sensitivity and positive predictive value (PPV) of various algorithms for confirming psoriasis (PsO) and psoriatic arthritis (PsA). Kaiser Permanente Autoimmune Disease Registry, Northern California, 1996–2009.*

Disease codes and rendering physician Chart Review**
Number in the population Number reviewed* No. of true positives No. of false positives Sensitivity (95% CI) PPV (95% CI) Estimated no. of true positives in the population
PsO without PsA
≥ 1 Any Physician 83,701 87 65 22 100*** 78
≥ 1 Dermatology 59,671 66 59 7 91 (80–96) 89 (79– 95) 53,342
≥ 2 Dermatology 39,835 43 41 2 63 95
≥ 1 Non-Dermatology 24,022 21 6 15 9 29
PsA without PsO
≥ 1 Any physician 1,061 107 57 50 100*** 53
≥ 1 Rheumatology 790 73 49 24 86 67
≥ 2 Rheumatology 605 54 44 10 77 (64–87) 81 (68–90) 493
≥ 1 Non-Rheumatology 271 34 8 26 14 24
PsO with PsA
≥ 1 Any physician 4,126 50 32 18 100*** 64 (49–77)
≥ 1 Dermatology AND ≥1 Rheumatology 3,427 35 25 10 78 (60–90) 71 (53–85) 2,448
Using the best performing algorithms****
PsO with or without PsA 63,098 101 91 10 88 (89–93) 90 (83–95) 55,790
PsA with or without PsO 4,032 89 71 18 73 (63–82) 80 (70–88) 2,941
*

The best performing algorithms are presented in bold.

**

A random sample of approximately 0.1% of patients with psoriasis codes alone, 1% of patients with psoriasis and psoriatic arthritis codes, and 10% of patients with psoriatic arthritis codes alone was selected, by assigning random numbers from 0–1.000 and selecting all cases with numbers below 0.001, 0.010, and 0.10, respectively, for validation by chart review.

***

By definition.

****

For PsO, ≥1 PsO diagnosis from dermatology. For PsA, ≥2 PsA diagnosis from rheumatology or ≥1 PsA diagnosis from rheumatology AND ≥1 PsO diagnosis from dermatology.