Figure 1.

A time line of discovery and clinical implementation of genomics to advance treatment of childhood ALL. A (orange): corresponds to time line for studies Total XI–XII in Figure 2; B (purple): corresponds to time line for studies Total XIII–XIV in Figure 2; C (blue): corresponds to time line for study Total XV in Figure 2; D (green): denotes future clinical use of genomics. ALL, acute lymphoblastic leukemia; SNP, single-nucleotide polymorphism; TPMT, thiopurine methyltransferase.