Figure 1. Msr1-deficient K/BxN mice are protected from arthritis and endocarditis.
(A) Arthritis severity in Msr1+/+ (filled squares, n = 7) and Msr1−/− (filled circles, n = 12) K/BxN mice was assessed at the indicated ages and is depicted as a qualitative score (left) and quantitative measurement (right) of ankle width. Plotted values are means ± SEM; p values are shown in the panels and were determined by repeated-measures ANOVA. (B) Same parameters as A in more detail for the Msr1−/− group of K/BxN mice; each line represents one mouse. (C) Serum-transferred arthritis was induced in Msr1+/− (open triangles, n = 5) and Msr1−/− (open circles, n = 5) B6 mice by injection of arthritogenic K/BxN serum on days 0 and 2 (arrows). Plotted values are means ± SEM; p values determined by repeated-measures ANOVA were not significantly different.