Table 1. Sequences, Biological activities of HP (2–20) and its analogues.
MIC (µM) | |||||||||||
Name | Sequence | G(+) | G(−) | Yeast | |||||||
BS | SE | SA | EC | PV | ST | PA | CA | TB | SC | ||
HP (2–20) | AKKVFKRLEKLFSKIQNDK-NH2 | 1.56 | 3.13 | 12.5 | 6.25 | 3.13 | 0.78 | 12.5 | 25 | 12.5–25 | 25 |
Anal 1 | AKKVFKRLEKLFSKIQNWK-NH2 | 1.56 | 0.78 | 3.13 | 1.56 | 1.56 | 0.39 | 6.25 | 12.5 | 6.25 | 12.5 |
Anal 2 | AKKVFKRLEKLFSKIWNDK-NH2 | 1.56 | 1.56 | 3.13 | 1.56 | 1.56 | 0.78 | 6.25 | 12.5 | 6.25–12.5 | 12.5 |
Anal 3 | AKKVFKRLEKLFSKIWNWK-NH2 | 0.78 | 0.78 | 1.56 | 0.78 | 1.56 | 0.39 | 3.13 | 6.25 | 3.13 | 3.13–6.25 |
Anal 4 | AKKVFKRLEKSFSKIQNDK-NH2 | 6.25 | 12.5 | >12.5 | 12.5 | 6.25 | 1.56 | >12.5 | 50–100 | 50 | 50 |
Anal 5 | AKKVSKRLEKLFSKIQNDK-NH2 | 3.13 | 6.25 | >12.5 | 6.25 | 3.13 | 3.13 | >12.5 | 100 | 50 | 50–100 |
Anal 3-Pro | AKKVFKRLPKLFSKIWNWK-NH2 | 0.39 | 0.39 | 0.39 | 0.19 | 0.09 | 0.09 | 1.56 | 3.13 | 1.56 | 1.56 |
G(+), Gram positive bacteria; G(−), Gram negative bacteria; BS, B. substilis; SE, S. epidermides; SA, S. aureus; EC,E. coli; PV, P. vulgalis; ST, S. typhimurium; PA, P. aeruginosa; CA, C. albicans; TB, T. beigellii; SC, S. cerevisiae.