Table II.
Derivation and In Vivo Characteristics of Original LuCaP Xenografts Cultured to date In Vitro
| LuCaP xenograft |
Source | Tissue Type |
Histology | Response to CX1 |
Response to DOC2 |
AR3 | PSA4 | Doubling Time (days) |
|---|---|---|---|---|---|---|---|---|
| 58 | OR5 | LN6 | adenocarcinoma | NR7 | HR8 | WT9 | Low | 15 |
| 92 | Autopsy | LN | adenocarcinoma | Pending | Pending | WT | High | 20 |
| 93 | OR | TURP10 | Small cell carcinoma | NR | IR11 | NA12 | NA | 18 |
| 96 | OR | TURP | adenocarcinoma | HR | NR | WT | High | 20 |
| 136 | OR | Ascites | adenocarcinoma | IR | IR | WT | Low | 20 |
| 147 | Autopsy | Liver | adenocarcinoma | NR | NR | Mut13 | Low | 25 |
1
Castration
2
Docetaxel
3
Androgen receptor
4
Prostate-specific antigen
5
Operating room
6
Lymph node
7
No response
8
Highly responsive
9
Wild-type
10
Transurethral resection of the prostate
11
Intermediate response
12
Not applicable
13
Mutated