Table 2. Cox proportional–hazards analysis of associations between allelic variants of metabolizing and DNA–repair genes and overall survival status among colorectal cancer patients.
| Variables | Patients | Events | MSM | HR (95% CI)a | P | FDR |
| GSTM1 | ||||||
| Null | 286 | 161 | 48.1 | 1 (reference) | ||
| Present | 205 | 107 | 50.1 | 0.81 (0.64–1.04) | 0.100 | 0.400 |
| GSTT1 | ||||||
| Null | 249 | 133 | 49.5 | 1 (reference) | ||
| Present | 242 | 135 | 47.6 | 1.15 (0.90–1.46) | 0.271 | 0.643 |
| GSTP1 Ile105Val | ||||||
| Ile/Ile | 336 | 183 | 48.8 | 1 (reference) | ||
| Ile/Val | 139 | 76 | 49.0 | 1.10 (0.84–1.44) | 0.482 | 0.643 |
| Val/Val | 16 | 9 | 38.9 | 1.12 (0.57–2.20) | 0.749 | 0.850 |
| Ile/Val+ Val/Val | 155 | 85 | 49.0 | 1.10 (0.85–1.43) | 0.459 | 0.643 |
| XRCC1 Arg399Gln | ||||||
| Arg/Arg | 249 | 126 | 57.1 | 1 (reference) | ||
| Arg/Gln | 212 | 126 | 42.3 | 1.12 (0.87–1.44) | 0.389 | 0.643 |
| Gln/Gln | 30 | 16 | 49.0 | 1.06 (0.63–1.79) | 0.827 | 0.850 |
| Arg/Gln + Gln/Gln | 242 | 142 | 43.0 | 1.11 (0.87–1.42) | 0.402 | 0643 |
| XRCC3 Thr241Met | ||||||
| Thr/Thr | 459 | 253 | 48.6 | 1 (reference) | ||
| Thr/Met | 32 | 15 | 49.3 | 1.05 (0.62–1.78) | 0.850 | 0.850 |
| Met/Met | 0 | 0 | 0 | – | – | – |
| XPD Lys751Gln | ||||||
| Lys/Lys | 404 | 216 | 49.0 | 1 (reference) | ||
| Lys/Gln | 84 | 49 | 47.8 | 1.34 (0.99–1.84) | 0.062 | 0.372 |
| Gln/Gln | 3 | 3 | 28.5 | 2.38 (0.75–7.53) | 0.141 | 0.423 |
| Lys/Gln + Gln/Gln | 87 | 52 | 47.1 | 1.38 (1.02–1.88) | 0.039 | 0.372 |
a
Adjusted for age, sex, and tumor-node-metastasis stage.
MSM: median survival month; FDR: false discovery rate.