Table 1. WGCNA Network Summary.
Whole Brain | Cerebe llum | Hippo campus | Nucleus Accumbens | Prefrontal Cortex | Striatum | Ventral Tegmental Area | |
Number of BXD RI Strains On Which Network is Based | 30 | 28 | 67 | 34 | 27 | 31 | 35 |
Number of Probesets Placed Into Modules | 28,867 | 26,109 | 18,949 | 16,632 | 19,288 | 21,687 | 20,550 |
Number of Modules Identified | 499 | 604 | 337 | 512 | 595 | 300 | 433 |
Minimum Module Size | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
Maximum Module Size | 2,881 | 4,270 | 3,185 | 2,928 | 2,144 | 3,903 | 3,440 |
Median Module Size | 9 | 8 | 8 | 9 | 8 | 9 | 9 |
Candidate Modules | |||||||
Number of Modules Significantly1 Correlated with Alcohol Consumption | 12 | 2 | 5 | 19 | 7 | 9 | 12 |
Modules Significantly Correlated with Alcohol Consumption and with mQTL/bQTL overlap (Candidate Modules) | 4 | 1 | 1 | 8 | 4 | 1 | 5 |
Minimum Proportion of Variance in Candidate Module(s) Captured by Eigengene | 91% | 98% | 99% | 88% | 82% | 97% | 83% |
Significant association with alcohol consumption is defined as FDR <0.05 or Fisher's unadjusted p-value <0.01 for the association between module eigengene and alcohol consumption (Rodriguez et al., 1994; Phillips et al., 1994).