Table 2. Characteristics of candidate modules associated with alcohol consumption.
| Brain Region | Module | Number of Probesets | Correlation Rodriguez (p-value) | Correlation Phillips (p-value) | Fisher's p-value (FDR) | Shared eQTL Location : Chr (Mb)/probesets with shared eQTL | mQTL location: Chr (Mb) | mQTL LOD score (p- value) | Hub Gene (Gene Symbol) |
| Whole Brain | deeppink1 | 16 | 0.29 (0.126) | 0.47 (0.008) | 8.33E-03 (0.379) | 4 (129.2–140.5)/16 | 4 (136.2) | 19.8 (<0.001) | calcium/calmodulin-dependent protein kinase II inhibitor 1 Gene (Camk2n1) |
| Whole Brain | gold3 | 6 | −0.37 (0.045) | −0.41 (0023) | 8.06E-03 (0.379) | 4 (154.9–155.4)/6 | 4 (155.2) | 17.4 (<0.001) | guanine nucleotide binding protein (G protein), beta 1 (Gnb1) |
| Whole Brain | hotpink3 | 9 | 0.62 (<0.001) | 0.53 (0.003) | 1.23E-05 (0.006) | 7 (121.8–127.2)/9 | 7 (124.4) | 8.5 (<0.001) | ribosomal protein S15A (Rps15a) |
| Whole Brain | slateblue | 18 | 0.35 (0.056) | 0.46 (0.010) | 4.91E-03 (0.345) | 9 (41.5–54.8)/17 | 9 (41.5) | 9.7 (<0.001) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d/Sc5dl) |
| Cerebellum | yellow4 | 34 | 0.74 (0.006) | 0.54 (0.056) | 2.79E-03 (0.99) | N/A | 13 (20.0) | 4.1 (0.039) | myeloid/lymphoid or mixed-lineage leukemia 3 (Mll3) |
| Hippocampus | navajowhite3 | 9 | 0.48 (0.045) | 0.76 (<0.001) | 3.25E-04 (0.11) | 2 (93.3)/8 | 2 (93.3) | 18.7 (<0.001) | low density lipoprotein receptor-related protein 4 (Lrp4) |
| Nucelus Accumbens | lightskyblue2 | 12 | −0.63 (0.007) | −0.79 (<0.001) | 4.52E-05 (0.021) | 2 (80.2–97.3)/12 | 2 (88.2) | 18.3 (<0.001) | RIKEN cDNA 2810002D19 gene (2810002D19Rik)* |
| Nucelus Accumbens | mediumorchid4 | 14 | −0.67 (0.003) | −0.73 (0.002) | 8.48E-05 (0.021) | 9 (56.7–62.2)/14 | 9 (56.7) | 18.0 (<0.001) | neogenin (Neo1) |
| Nucelus Accumbens | rosybrown3 | 10 | 0.67 (0.003) | 0.71 (0.003) | 1.21E-04 (0.021) | 9 (51.5–68.2)/10 | 9 (51.8) | 16.1 (<0.001) | ELMO domain-containing protein 1 ( Elmod1) |
| Nucelus Accumbens | honeydew | 27 | 0.36 (0.158) | 0.72 (0.002) | 3.33E-03 (0.182) | 9 (35.8–41.5)/22 | 9 (41.5) | 21.6 (<0.001) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d) |
| Nucelus Accumbens | lightblue1 | 12 | 0.33 (0.196) | 0.72 (0.002) | 3.86E-03 (0.182) | 4 (126.2–129.2)/12 | 4 (129.2) | 21.4 (<0.001) | protein tyrosine phosphatase 4a2 (Ptp4a2) |
| Nucelus Accumbens | limegreen | 10 | −0.70 (0.002) | −0.31 (0.261) | 4.05E-03 (0.182) | 11 (101.5–108.1)/10 | 11 (101.5) | 17.8 (<0.001) | LSM12 homolog (S. cerevisiae) (Lsm12) |
| Nucelus Accumbens | rosybrown2 | 9 | 0.50 (0.042) | 0.63 (0.011) | 4.18E-03 (0.182) | 9 (35.0–48.0)/9 | 9 (48.0) | 19.0 (<0.001) | asparagine-linked glycosylation 9 homolog (yeast, alpha 1,2 mannosyltransferase) (Alg9) |
| Nucelus Accumbens | navajowhite1 | 28 | 0.44 (0.077) | 0.62 (0.014) | 8.52E-03 (0.269) | 4 (108.2–122.5)/28 | 4 (114.5) | 22.1 (<0.001) | mediator of RNA polymerase II transcription, subunit 8 homolog (yeast) (Med8) |
| Prefrontal Cortex | salmon3 | 7 | 0.71 (0.001) | 0.64 (0.010) | 1.64E-04 (0.097) | 7 (125.2–126.9)/5 | 7 (124.4) | 10.0 (<0.001) | ribosomal protein S15A (Rps15a) |
| Prefrontal Cortex | lightsteelblue1 | 37 | 0.46 (0.063) | 0.70 (0.004) | 2.19E-03 (0.533) | 9 (29.7–56.7)/29 | 9 (46.0) | 16.4 (<0.001) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d) |
| Prefrontal Cortex | darkorange.1 | 6 | −0.58 (0.015) | −0.52 (0.049) | 5.89E-03 (0.702) | 2 (75.9–83.3)/5 | 2 (79.2) | 9.2 (<0.001) | frizzled-related protein (Frzb) |
| Prefrontal Cortex | bisque4.1 | 6 | 0.64 (0.005) | 0.35 (0.196) | 8.37E-03 (0.714) | 9 (28.1)/5 | 9 (28.1) | 8.3 (0.016) | dentin matrix protein 1 (Dmp1) |
| Striatum | burlywood3 | 5 | 0.52 (0.020) | 0.53 (0.025) | 4.32E-03 (0.26) | 7 (122.6–124.4)/5 | 7 (124.4) | 15.6 (<0.001) | ribosomal protein S15A (Rps15a) |
| Ventral Tegmental Area | aquamarine4 | 6 | 0.67 (0.003) | 0.81 (<0.001) | 1.18E-05 (0.01) | 9 (51.8–62.2)/6 | 9 (56.7) | 14.7 (<0.001) | reticulocalbin 2 (Rcn2) |
| Ventral Tegmental Area | snow2 | 7 | 0.51 (0.037) | 0.78 (0.001) | 2.58E-04 (0.06) | 9 (48.0)/7 | 9 (48.0) | 22.6 (<0.001) | family with sequence similarity 55, member D (Fam55d) |
| Ventral Tegmental Area | tomato2 | 11 | 0.69 (0.002) | 0.49 (0.061) | 1.29E-03 (0.14) | 7 (120.9–126.9)/10 | 7 (125.0) | 19.2 (<0.001) | ribosomal protein S15A (Rps15a) |
| Ventral Tegmental Area | mediumturquoise | 6 | −0.67 (0.003) | −0.48 (0.069) | 2.03E-03 (0.15) | 11 (101.5–103.8)/6 | 11 (101.5) | 14.0 (<0.001) | LSM12 homolog (S. cerevisiae) (Lsm12) |
| Ventral Tegmental Area | indianred3 | 21 | 0.30 (0.243) | 0.71 (0.003) | 6.35E-03 (0.26) | 9 (34.9–50.5)/21 | 9 (41.5) | 24.3 (<0.001) | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d) |
Candidate modules from all whole brain and each brain regional network are shown. The first column depicts the network from which the candidate module was derived and the second column is the module name. The direction of the correlation is not reported as these are unsigned networks. N/A indicates there were no common eQTLs among the probesets. The mQTL location reports the chromosome and Mb location for the highest peak.