Table 2. Identification of protective protein antigens against Streptococcus pneumoniae infection already described in literature.

Protein family	Antigen	Locus	Location	References	Found in # strains
Choline-binding proteins	PspA	spr0121	1TMD	[53]	14/16
	CbpA (PspC)	spr1995	Secreted	[41]	16/16
	PcpA	spr1945	Secreted	[45]	5/16
	LytA	spr1754	Cytoplasmic	[47]	3/16
	LytB	spr0867	>1TMD	[52]	7/16
Toxins	Ply	spr1739	Cytoplasmic	[40]	6/16
Sortase and sortase-dependent proteins	SrtA	spr1098	1TMD	[44]	4/16
	RrgA	SP_0462	Cell Wall	[43]	0/16
	RrgB	SP_0463	Cell Wall	[43]	0/16
	RrgC	SP_0464	Cell Wall	[43]	0/16
	NanA	spr1536	Cell Wall	[48]	13/16
	SphtrA	spr2045	1TMD	[52]	11/16
ABC transporter proteins	PiaA (ABC-SBP)	spr0934	Lipoprotein	[46]	2/16
	PiuA (fecE)	spr1686	Cytoplasmic	[46]	2/16
	PsaA	spr1494	>1TMD	[51]	2/16
	PotD	spr1243	1TMD	[50]	1/16
	sp0148 (ABC-SBP)	spr0146	Lipoprotein	[49]	5/16
Enzymatic proteins	ClpP	spr0656	Cytoplasmic	[42]	1/16
	StkP	spr1577	1TMD	[54]	1/16
	FBA	spr0530	Cytoplasmic	[34]	13/16
	gapA	spr1825	Cytoplasmic	[34]	16/16
	eno	spr1036	Cytoplasmic	[56]	16/16
	tig	spr0362	Cytoplasmic	[56]	9/16
	ldh	spr1100	Cytoplasmic	[56]	11/16
	pykF	spr0797	Cytoplasmic	[56]	15/16
	pgk	spr0441	Cytoplasmic	[56]	15/16
	gnd	spr0335	Cytoplasmic	[34]	13/16
Histidine triad proteins	PhtA	spr1061	Lipoprotein	[55]	6/16
	PhtB	spr1060	Lipoprotein	[55]	9/16
	PhtD	spr0907	1TMD	[55]	14/16
	PhtE	spr0908	Secreted	[55]	10/16
Others	PcsB	spr2021	Secreted	[54]	12/16
	PppA	spr1430	Cytoplasmic	[59]	6/16
	PpmA (PrsA)	spr0884	Lipoprotein	[62]	8/16
	SlrA	spr0679	Cytoplasmic	[60]	11/16
	AmiA	spr1707	Lipoprotein	[61]	5/16
	AliB	spr1382	Lipoprotein	[61]	9/16
	AliA	spr0327	Lipoprotein	[61]	7/16
	PfbB	spr0075	Cell Wall	[63]	8/16
	PsrP	sp_1772	Cell Wall	[64]	0/16
	spr0785	spr0785	Cytoplasmic	[49]	1/16
	spr1176	spr1176	Cytoplasmic	[58]	1/16
	spr2010	spr2010	>1TMD	[58]	1/16
	spr1875	spr1875	1TMD	[57]	8/16