Table 2. Identification of protective protein antigens against Streptococcus pneumoniae infection already described in literature.
Protein family | Antigen | Locus | Location | References | Found in # strains |
Choline-binding proteins | PspA | spr0121 | 1TMD | [53] | 14/16 |
CbpA (PspC) | spr1995 | Secreted | [41] | 16/16 | |
PcpA | spr1945 | Secreted | [45] | 5/16 | |
LytA | spr1754 | Cytoplasmic | [47] | 3/16 | |
LytB | spr0867 | >1TMD | [52] | 7/16 | |
Toxins | Ply | spr1739 | Cytoplasmic | [40] | 6/16 |
Sortase and sortase-dependent proteins | SrtA | spr1098 | 1TMD | [44] | 4/16 |
RrgA | SP_0462 | Cell Wall | [43] | 0/16 | |
RrgB | SP_0463 | Cell Wall | [43] | 0/16 | |
RrgC | SP_0464 | Cell Wall | [43] | 0/16 | |
NanA | spr1536 | Cell Wall | [48] | 13/16 | |
SphtrA | spr2045 | 1TMD | [52] | 11/16 | |
ABC transporter proteins | PiaA (ABC-SBP) | spr0934 | Lipoprotein | [46] | 2/16 |
PiuA (fecE) | spr1686 | Cytoplasmic | [46] | 2/16 | |
PsaA | spr1494 | >1TMD | [51] | 2/16 | |
PotD | spr1243 | 1TMD | [50] | 1/16 | |
sp0148 (ABC-SBP) | spr0146 | Lipoprotein | [49] | 5/16 | |
Enzymatic proteins | ClpP | spr0656 | Cytoplasmic | [42] | 1/16 |
StkP | spr1577 | 1TMD | [54] | 1/16 | |
FBA | spr0530 | Cytoplasmic | [34] | 13/16 | |
gapA | spr1825 | Cytoplasmic | [34] | 16/16 | |
eno | spr1036 | Cytoplasmic | [56] | 16/16 | |
tig | spr0362 | Cytoplasmic | [56] | 9/16 | |
ldh | spr1100 | Cytoplasmic | [56] | 11/16 | |
pykF | spr0797 | Cytoplasmic | [56] | 15/16 | |
pgk | spr0441 | Cytoplasmic | [56] | 15/16 | |
gnd | spr0335 | Cytoplasmic | [34] | 13/16 | |
Histidine triad proteins | PhtA | spr1061 | Lipoprotein | [55] | 6/16 |
PhtB | spr1060 | Lipoprotein | [55] | 9/16 | |
PhtD | spr0907 | 1TMD | [55] | 14/16 | |
PhtE | spr0908 | Secreted | [55] | 10/16 | |
Others | PcsB | spr2021 | Secreted | [54] | 12/16 |
PppA | spr1430 | Cytoplasmic | [59] | 6/16 | |
PpmA (PrsA) | spr0884 | Lipoprotein | [62] | 8/16 | |
SlrA | spr0679 | Cytoplasmic | [60] | 11/16 | |
AmiA | spr1707 | Lipoprotein | [61] | 5/16 | |
AliB | spr1382 | Lipoprotein | [61] | 9/16 | |
AliA | spr0327 | Lipoprotein | [61] | 7/16 | |
PfbB | spr0075 | Cell Wall | [63] | 8/16 | |
PsrP | sp_1772 | Cell Wall | [64] | 0/16 | |
spr0785 | spr0785 | Cytoplasmic | [49] | 1/16 | |
spr1176 | spr1176 | Cytoplasmic | [58] | 1/16 | |
spr2010 | spr2010 | >1TMD | [58] | 1/16 | |
spr1875 | spr1875 | 1TMD | [57] | 8/16 |