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. 2013 Jul 23;8(7):e70195. doi: 10.1371/journal.pone.0070195

Figure 1. Mice lacking Smad7 develop more severe cardiac dysfunction.

Figure 1

(A) Effect of Smad7 deletion on the systolic blood pressure in response to Ang II infusion. (B) Representative echocardiography at day 28 after saline or Ang II infusion in Smad7 WT and KO mice. Results show that Smad7 KO mice significantly increase LV mass, reduce LVEF and FS when compared with Smad7 WT mice after Ang II infusion. Data represent the mean±SE for a group of 6 mice. **P<0.01, ***P<0.001 vs saline control; ##P<0.01, ###P<0.001 vs Ang II–infused Smad7 WT mice.