Table 1. Alleles associated with the heph locus.

allele	mutagen	mutation	viable	complementation deficiency DfG45	complementation heph03429	origin
hephe2	EMS	deletion of RRMs 1, 2 and part of 3	no	no	no	Dansereau et al. [64]
hephe1	EMS	point mutation (G to Q in RRM1)	no	no	no	Dansereau et al. [64]
heph03429	P-element	insertion at position 27756259 (intron)	no	no	–	Besse et al. [55]

A number of alleles map to the heph locus. Two EMS-induced alleles, heph^e1 and heph^e2, alter RRM domains. heph^e2 is a deletion of several coding exons including the coding region for RRM1, RRM2 and part of RRM3. heph^e1 is a mis-sense mutation that changes a glycine (G) to a glutamine (Q) in RRM1. The P-element allele heph⁰³⁴²⁹ [64] maps to a heph intron.

doi:10.1371/journal.pone.0069978.t001