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. 2013 Jul 23;8(7):e70005. doi: 10.1371/journal.pone.0070005

Figure 5. Destabilizing effect of mutation E374K.

Figure 5

A, wild-type HA; B, E374K mutant. Protein is shown as green ribbons. Amino acids surrounding position 374 are illustrated as sticks. In the wild-type HA, E374 interacts with Y433 and N366 and with the fusion peptide through water-mediated hydrogen bonds. In E374K, the lysine residue interacts only with the oxygen from the amide group of N366.