Table 1.
Cardiac function in mice at 2 week post-MI with and without MGF E-peptide treatment
| Group parameter | Control | Control + SCR-peptide | Control + E-peptide | 2 week MI | 2 week MI + SCR-peptide | 2 week MI + E-peptide |
|---|---|---|---|---|---|---|
| HR | 594 ± 20 | 546 ± 25 | 526 ± 24 | 555 ± 17 | 565 ± 27 | 530 ± 16 |
| MAP | 80 ± 2.5 | 71 ± 1.9 | 74 ± 1.3 | 61 ± 5* | 66 ± 4.0* | 76 ± 3.6† |
| EDV | 46 ± 1.0 | 47 ± 4.0 | 50 ± 3.0 | 66 ± 3.1* | 69 ± 3.0* | 68 ± 2.4* |
| ESV | 25 ± 0.7 | 24 ± 0.8 | 27.5 ± 1.0 | 53 ± 3.3* | 58 ± 2.5* | 55 ± 3.5* |
| V int | 22.4 ± 1.4 | 21.2 ± 0.8 | 24 ± 1.3 | 38.9 ± 4* | 49 ± 2.7* | 39.6 ± 3.5* |
| ESP | 102 ± 2.2 | 102 ± 8.8 | 93 ± 2.0 | 77 ± 3.1* | 79 ± 3.0* | 92 ± 3.5† |
| EDP | 6.8 ± 0.7 | 7.0 ± 1.0 | 6.7 ± 0.8 | 9.7 ± 1.5* | 9.7 ± 1.7* | 8.2 ± 1.4* |
| SV | 20.8 ± 0.7 | 22.6 ± 2.7 | 22.4 ± 1.0 | 12.2 ± 1.7* | 12.9 ± 0.7* | 15.1 ± 1.4* |
| CO | 12,138 ± 972 | 11,879 ± 1,835 | 11,891 ± 742 | 6,987 ± 871* | 6,850 ± 650* | 7,938 ± 933* |
| SW | 1,645 ± 60 | 1,749 ± 199 | 1,645 ± 170 | 645 ± 72* | 713 ± 77* | 1,236 ± 154*,† |
| dP/dtmax | 11,321 ± 560 | 10,053 ± 346 | 8,957 ± 337 | 5,692 ± 311* | 6,085 ± 409* | 10,357 ± 240† |
| dP/dtmin | −10,344 ± 617 | −8,704 ± 237 | −8,632 ± 235 | −5,562 ± 546* | −5,988 ± 418* | −8,918 ± 285† |
| Tau-G | 8.3 ± 0.6 | 8.7 ± 1.1 | 7.3 ± 0.3 | 15.4 ± 3.5* | 10.3 ± 0.8* | 9.7 ± 0.5* |
| PAMP | 60.6 ± 7.6 | 55.6 ± 5.3 | 48 5 ± 6.1 | 9.6 ± 1.2* | 8.6 ± 1.0* | 23.0 ± 2.0* |
| TPR | 6.8 ± 0.6 | 6.3 ± 0.7 | 6.4 ± 0.5 | 10.2 ± 1.6* | 10.4 ± 1.3* | 9.3 ± 1.0* |
| E a | 4.6 ± 0.23 | 4.6 ± 0.8 | 4.5 ± 0.5 | 6.6 ± 0.6* | 7.7 ± 0.7* | 7.5 ± 0.6* |
| E a/E s | 0.20 ± 0.01 | 0.23 ± 0.04 | 0.28 ± 0.04 | 0.84 ± 0.06* | 0.71 ± 0.11* | 0.60 ± .0.04*,† |
Pressure–volume loop measurements collected in the closed chest configuration
HR Heart rate (beats per minute), MAP mean arterial pressure (mmHg), EDV end diastolic volume (μl), ESV end systolic volume (μl), V int volume intercept (μl), ESP end-systolic pressure (mmHg), EDP end-diastolic pressure (mmHg), SV stroke volume (μl), CO cardiac output (μl/min), SW stroke work (mmHg/μl), dP/dt max maximum first derivative of change in systolic pressure with respect to time (mmHg/s), dP/dt min maximum first derivative of change in diastolic pressure with respect to time (mmHg/s), Tau-Glantz-time constant of fall in ventricular pressure by Glantz method (ms), PAMP preload adjusted maximal power (mWatts/ml2), TPR total peripheral resistance (mmHg/ml/min), E a /E s vascular-to-ventricular coupling
* P < 0.05 versus control; † P < 0.05 versus 2 week MI (n = 6 per group)