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CD14 has three fundamental functions. Panel 1, CD14 favors optimal NF-kB-dependent cytokine production by allowing the recognition of low-LPS doses. Panel 2, CD14 promotes TLR4 endocytosis and type-I IFN expression. Panel 3, CD14 has autonomous signaling functions leading to the activation of NFATc transcription factor family members. The consequences of NFAT activation are mostly unknown.
