Table 1.
Offspring brain mass.
| Sample size | Brain mass (g) | Normal. brain mass (% body g) | ||||
|---|---|---|---|---|---|---|
| CTR | VPA | CTR | VPA | CTR | VPA | |
| MALE | ||||||
| P1 | 5 | 5 | 0.29 ± 0.01 | 0.27 ± 0.01* | 4.26 ± 0.23 | 3.99 ± 0.12! |
| P14 | 21 | 22 | 1.21 ± 0.02 | 1.08 ± 0.02* | 3.93 ± 0.11 | 3.74 ± 0.14! |
| FEMALE | ||||||
| P1 | 5 | 51 | 0.27 ± 0.004 | 0.25 ± 0.003* | 4.04 ± 0.26 | 3.98 ± 0.21! |
| P14 | 24 | 18 | 1.14 ± 0.41 | 1.01 ± 0.03* | 4.06 ± 0.12 | 3.74 ± 0.16! |
Absolute and normalized brain mass means and S.E.M. of males or females offspring at Postnatal day 1 (P1) or 14 (P14), after embryonic exposure to saline (CTR) or valproic acid (VPA, 500 mg/kg).
*
, significantly different from same-sex same-age controls (CTR).
1
, sample size of 4 animals for normalized brain mass.
!
, No statistical tests were applied on normalized brain mass.