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. Author manuscript; available in PMC: 2014 Jun 6.
Published in final edited form as: Mol Cell. 2013 Jun 6;50(5):686–698. doi: 10.1016/j.molcel.2013.05.012

Figure 5. SIRT4 KO mice display an altered lipid metabolism in vivo.

Figure 5

(A) Triglyceride composition from WAT from WT and SIRT4 KO fed and fasted mice (n=3 mice per genotype, per condition). (B–C) Skeletal Muscle (quadriceps) phospholipid and triglyceride composition from WT and SIRT4 KO fed and fasted mice (n=3 mice per genotype, per condition). (D–E) Exercise tolerance assays were performed on WT and SIRT4 KO mice (n=11–14 per genotype). (F–G) RER in WT and SIRT4 KO mice during exercise (F) and recovery (G) (n=11–14). (H–J) De novo lipogenesis in vivo was measured by determining incorporation of deuterated water into palmitate in WAT (H), liver (I), and plasma (J) (n=6 per genotype). In each panel, data represent mean ± SEM. (*) p < 0.05; (**) p < 0.01, (***) p < 0.001. See also Figure S3.