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. 2013 Jul 24;6:6. doi: 10.3389/fneng.2013.00006

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Copyright © 2013 Richter, Xie, Schumacher, Loeffler, Kirch, Al-Hasani, Rapoport, Kruse, Moser, Tronnier, Danner and Hofmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Micrograph of the implantation area one week after implantation 4,5 mm below the brain surface. The rod supported insertion of the microprobe yields an implantation channel on one side of the slightly crescent-shaped probe (350 μm wide). Invading cells to this region are indicated by stained nuclei (DAPI, blue). A thin glial layer (glial fibrillary acidic protein, green) surrounds the lesion and reflects a mild tissue reaction. The lack of a pronounced extracellular matrix layer (chondroitinsulfate proteoglycan, red) supports this observation. The brain-probe-interface showed no cysts. Magnification 20x with an PlanApochromat-Objective at AxioObserver Z.1 (Carl Zeiss MicroImaging GmbH, Germany).