Table 2. Clinicopathological data and HPV infection.
| Characteristic Clinicopathological | ValueN (%) | N/total HPV positive (%) | P-value |
|---|---|---|---|
| Age (years), median (range) | 68.75 (46-90) | – | – |
| 46–49 years old | 30 (34.5) | 11/34 (32.3) | 0.067 |
| ⩾50 years old |
57 (65.5) |
23/34 (67.7) |
|
|
Histologic types | |||
| Grade 1 SCC | 27 (31) | 9/34 (26.5) | — |
| Grade 2 SCC | 46 (52.9) | 13/34 (38.2) | — |
| Grade 3 SCC | 8 (9.2) | 5/34 (14.7) | — |
| Basaloid Ca | 4 (4.6) | 4/34 (11.8) | — |
| Verrucous Ca |
2 (2.3) |
0 |
— |
|
Inflammatory infiltrate | |||
| No | 79 (90.8) | 16/57 (28.1) | 0.951 |
| Yes |
8 (9.2) |
29/40 (72.5) |
|
|
Vascular/perineural invasion | |||
| No | 73 (84) | 47/56 (83.9) | 0.445 |
| Yes |
14 (13) |
4/38 (10.5) |
|
|
Lymph node involvement | |||
| ⩽2 | 80 (92) | 28/30 (93.3) | 1.000 |
| >2 | 2 (2.3) | 2/23 (8.7) | |
| No |
5 (5.7) |
|
|
|
Associated lesions | |||
| VIN | 25 (29) | 8/22 (36.4) | 0.683 |
| Lichen sclerosus and squamous hyperplasia | 8 (9) | 4/10 (40) | |
| No |
54 (62) |
|
|
|
Invasion depth | |||
| Superficial and mid dermis | 37 (42.5) | 32/59 (54.2) | 0.570 |
| Deep dermis and subcutis |
50 (57.5) |
16/40 (40) |
|
|
FIGO stage | |||
| I and II | 56 (64.4) | 30/55 (54.5) | 0.179 |
| III and IV | 31 (35.6) | 12/38 (31.6) | |
Abbreviations: ⩽2=two or less lymph node involvement; >2=more than two lymph node involvement; FIGO=International Federation of Gynecology and Obstetrics; HPV=human papillomavirus; VIN=vulvar intraepithelial neoplasia (differentiated and high grade).
χ2-test (N=87).