Table 1.
Significant (p value≤9.19×10−5) ICD-9-CM codes and CCS groups from the MIMIC II analysis, with associated p values
| ICD-9-CM or CCS | Description | O:E Ratio | p Value |
|---|---|---|---|
| CCS 207 | Pathological fracture | 30.7 | 6.02×10−17 |
| V42.81 | Bone marrow replaced by transplant | 53.4 | 1.20×10−14 |
| 285.22 | Anemia in neoplastic disease | 24.8 | 2.10×10−14 |
| CCS 259 | Residual codes; unclassified | 5.8 | 4.82×10−13 |
| 733.13 | Pathologic fracture of vertebrae | 23.4 | 3.90×10−12 |
| CCS 2617 | E codes: adverse effects of medical drugs | 8.2 | 5.67×10−10 |
| 996.85 | Complications of transplanted; bone marrow, graft-versus-host disease (acute) (chronic) | 24.6 | 2.30×10−09 |
| CCS 58 | Other nutritional; endocrine; and metabolic disorders | 15.5 | 3.42×10−08 |
| V42.82 | Transplant; peripheral stem cells | 54.5 | 5.00×10−08 |
| CCS 63 | Diseases of white blood cells | 10.3 | 2.51×10−07 |
| CCS 81 | Other hereditary and degenerative nervous system conditions | 17.3 | 5.60×10−07 |
| CCS 2 | Septicemia (except in labor) | 2.9 | 9.85×10−07 |
| CCS 3 | Bacterial infection; unspecified site | 4.1 | 1.66×10−06 |
| CCS 133 | Other lower respiratory disease | 8.8 | 3.78×10−06 |
| 117.3 | Aspergillosis, Infection by Aspergillus species, mainly A fumigatus, A flavus group, A terreus group | 22.2 | 4.00×10−06 |
| CCS 122 | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 4.3 | 4.64×10−06 |
| CCS 4 | Mycoses | 6.9 | 8.77×10−06 |
| CCS 157 | Acute and unspecified renal failure | 2.4 | 1.11×10−05 |
| CCS 209 | Other acquired deformities | 68.4 | 1.97×10−05 |
| CCS 95 | Other nervous system disorders | 3.9 | 2.83×10−05 |
| 584.9 | Acute kidney failure, unspecified | 2.2 | 3.00×10−05 |
| CCS 237 | Complication of device; implant or graft | 3.3 | 3.58×10−05 |
| 275.42 | Hypercalcemia | 13.9 | 3.70×10−05 |
| 288 | Neutropenia | 21.4 | 4.40×10−05 |
Entries shown in italic were considered to be a marker for treatment-related complications and were used for subsequent SHRINE queries. O:E, observed:expected occurrence of code/group, patients with MM versus general MIMIC II population.
CCS, Clinical Classifications Software; ICD-9-CM, International Classification of Disease, Ninth Revision, Clinical Modification; MIMIC, Multiparameter Intelligent Monitoring in Intensive Care; MM, multiple myeloma; SHRINE, Shared Health Research Information Network.