Table 2.

Protein interaction datasets

	Protein interaction datasets details
Retrieved from	http://string.embl.de
STRING versions used	V.6.3 (Jan 2007)
	V.8.2 (May 2010)
Resulting dataset	14 025 Distinct human proteins
	492 087 Protein–protein interactions

The protein interaction networks is downloaded using the search tool for the retrieval of interacting genes, STRING.²⁶ To ensure the independence of the network from the published genome-wide association study results, protein interactions derived only from text mining were removed (see supplementary methods, available online only).