Table 1. New Chemical Entities and Medical Indications by Source of Compound 01.01.81-12.31.2010a.
| indication | total | B | N | NB | ND | S | S/NM | S* | S*/NM | V |
|---|---|---|---|---|---|---|---|---|---|---|
| COPD | 4 | 1 | 3 | |||||||
| analgesic | 17 | 1 | 11 | 3 | 2 | |||||
| anesthetic | 5 | 5 | ||||||||
| anti-Alzheimer | 4 | 1 | 3 | |||||||
| anti-Parkinsonian | 12 | 2 | 1 | 5 | 4 | |||||
| antiallergic | 17 | 1 | 1 | 4 | 11 | |||||
| antianginal | 5 | 5 | ||||||||
| antiarrhythmic | 17 | 1 | 14 | 2 | ||||||
| antiarthritic | 17 | 6 | 1 | 1 | 3 | 6 | ||||
| antiasthmatic | 14 | 1 | 3 | 2 | 6 | 2 | ||||
| antibacterial | 118 | 10 | 67 | 26 | 1 | 14 | ||||
| anticancer | 128 | 24 | 11 | 1 | 32 | 20 | 16 | 11 | 8 | 5 |
| anticoagulant | 19 | 5 | 13 | 1 | ||||||
| antidepressant | 23 | 7 | 14 | 2 | ||||||
| antidiabetic | 37 | 18 | 1 | 5 | 4 | 8 | 1 | |||
| antiemetic | 11 | 1 | 2 | 8 | ||||||
| antiepileptic | 15 | 2 | 9 | 2 | 2 | |||||
| antifungal | 29 | 1 | 3 | 22 | 3 | |||||
| antiglaucoma | 14 | 5 | 5 | 1 | 3 | |||||
| antihistamine | 13 | 13 | ||||||||
| antihyperprolactinemia | 4 | 4 | ||||||||
| antihypertensive | 79 | 2 | 28 | 14 | 2 | 33 | ||||
| antiinflammatory | 51 | 1 | 13 | 37 | ||||||
| antimigraine | 10 | 2 | 1 | 7 | ||||||
| antiobesity | 4 | 1 | 3 | |||||||
| antiparasitic | 14 | 2 | 5 | 4 | 2 | 1 | ||||
| antipsoriatic | 9 | 3 | 1 | 3 | 1 | 1 | ||||
| antipsychotic | 10 | 3 | 5 | 2 | ||||||
| antithrombotic | 29 | 13 | 1 | 5 | 2 | 6 | 2 | |||
| antiulcer | 34 | 1 | 1 | 12 | 20 | |||||
| antiviral | 110 | 14 | 4 | 9 | 2 | 23 | 10 | 48 | ||
| anxiolytic | 10 | 8 | 2 | |||||||
| benign prostatic | ||||||||||
| hypertrophy | 4 | 1 | 1 | 1 | 1 | |||||
| bronchodilator | 8 | 2 | 6 | |||||||
| calcium metabolism | 20 | 8 | 9 | 3 | ||||||
| cardiotonic | 13 | 3 | 2 | 3 | 5 | |||||
| chelator | 4 | 4 | ||||||||
| contraception | 9 | 8 | 1 | |||||||
| diuretic | 6 | 4 | 2 | |||||||
| erythropoiesis | 5 | 5 | ||||||||
| gastroprokinetic | 4 | 1 | 2 | 1 | ||||||
| hematopoiesis | 6 | 6 | ||||||||
| hemophilia | 12 | 12 | ||||||||
| hormone | 22 | 12 | 10 | |||||||
| hormone replacement therapy | 8 | 8 | ||||||||
| hypnotic | 12 | 12 | ||||||||
| hypocholesterolemic | 13 | 4 | 1 | 2 | 1 | 5 | ||||
| hypolipidemic | 8 | 1 | 7 | |||||||
| immunomodulator | 4 | 2 | 1 | 1 | ||||||
| immunostimulant | 11 | 5 | 3 | 2 | 1 | |||||
| immunosuppressant | 12 | 4 | 5 | 3 | ||||||
| irritable bowel syndrome | 4 | 1 | 3 | |||||||
| male sexual dysfunction | 4 | 4 | ||||||||
| multiple sclerosis | 6 | 3 | 1 | 1 | 1 | |||||
| muscle relaxant | 10 | 4 | 2 | 1 | 3 | |||||
| neuroleptic | 9 | 1 | 6 | 2 | ||||||
| nootropic | 8 | 3 | 5 | |||||||
| osteoporosis | 5 | 3 | 1 | 1 | ||||||
| platelet aggregation inhibitor | 4 | 3 | 1 | |||||||
| respiratory distress syndrome | 6 | 3 | 1 | 1 | 1 | |||||
| urinary incontinence | 5 | 2 | 3 | |||||||
| vulnerary | 5 | 2 | 2 | 1 | ||||||
| Grand Total | 1130 | 144 | 47 | 3 | 247 | 325 | 130 | 50 | 116 | 68 |
Diseases where ≤ 3 drugs approved 1981 – 2010; 225 drugs fall into this category and are subdivided as follows: B, 58; N, 12; NB, 2; ND, 52; S, 62, S/NM. 16; S*, 5; S*/NM, 6; V, 12. The diseases covered the following; 5 α-reductase inhibitor, ADHD, CAPS, CHF, CNS Stimulant, Crohn's disease, DVT, Fabry's disease, Gaucher's disease, Hunter syndrome, Japanese encephalitis, Lambert-Eaton Myasthenic Syndrome, Lyme disease, MI, acute, MMRC, PAH, PCP/Toxoplasmosis, PNH, Pompe's disease, Turner Syndrome, abortifacient, acromelagy, actinic keratoses, adjuvant/colorectal cancer, alcohol deterrent, allergic rhinitis, anabolic metabolism, analeptic, anemia, anti sickle cell anemia, anti-smoking, antiacne, antiathersclerotic, anticonvulsant, antidiarrheal, antidote, antiemphysemic, antihyperuricemia, antihypotensive, antinarcolepsy, antinarcotic, antinauseant, antiperistaltic, antipneumococcal, antiprogestogenic, antirheumatic, antisecretory, antisepsis, antiseptic, antispasmodic, antispastic, antitussive, antityrosinaemia, antixerostomia, atrial fibrillation, benzodiazepine antagonist, β-lactamase inhibitor, blepharospasm, bone disorders, bone morphogenesis, bowel evacuant, cardioprotective, cardiovascular disease, cartilage disorders, cervical dystonia, choleretic, chronic idiopathic constipation, cognition enhancer, congestive heart failure, constipation, cystic fibrosis, cytoprotective, dementia (Alzheimer's), diabetic foot ulcers, diabetic neuropathies, digoxin toxicity, dpt, dry eye syndrome, dyslipidemia, dysuria, endometriosis, enzyme, expectorant, fertility inducer, gastroprotectant, genital warts, hematological, hemorrhage, hemostasis, hemostatic, hepatoprotectant, hereditary angioedema, homocystinuria, hyperammonemia, hyperparathyroidism, hyperphenylalaninemia, hyperphosphatemia, hyperuricemia, hypoammonuric, hypocalciuric, hypogonadism, hyponatremia, idiopathic pulmonary fibrosis, idiopathic thrombocytopenia, immediate allergy, infertility (female), inflammatory bowel disease, insomnia, joint lubricant, lipoprotein disorders, macular degeneration, mucolytic, mucopolysaccharidosis, mucositis, myleodysplasia, narcolepsy, nasal decongestant, neuropathic pain, neuroprotective, ocular inflammation, opiate detoxification, osteoarthritis, overactive bladder, ovulation, pancreatic disorders, pancreatitis, pertussis, photosensitizer, pituitary disorders, porphyria, premature birth, premature ejaculation, progestogen, psychostimulant, pulmonary arterial hypertension, purpura fulminans, rattlesnake antivenom, reproduction, restenosis, schizophrenia, sclerosant, secondary hyperthryoidism, sedative, skin photodamage, strabismus, subarachnoid hemorrhage, thrombocytopenia, treatment of GH deficiency, ulcerative colitis, urea cycle disorders, uremic pruritis, urolithiasis, vaccinia complications, varicella (chicken pox), vasodilator, vasodilator (cerebral), vasodilator (coronary), vasoprotective, venous thromboembolism